Shuo Lin
shuolin@ucla.edu
310-267-4970
BSRB 490C
Los Angeles, CA 90095 4325 Life Sciences Building
Campus - 160606
CA Life Science Building
Los Angeles, CA 90095
Lab Number:
(310) 267-4972
Affiliations
Director, Zebrafish
Professor, Molecular, Cell, and Developmental Biology
Member, Brain Research Institute, California NanoSystems Institute, Cell & Developmental Biology GPB Home Area, Gene Regulation GPB Home Area, Genetics & Genomics GPB Home Area, JCCC Cancer and Stem Cell Biology Program Area
Professor, Molecular, Cell, and Developmental Biology
Member, Brain Research Institute, California NanoSystems Institute, Cell & Developmental Biology GPB Home Area, Gene Regulation GPB Home Area, Genetics & Genomics GPB Home Area, JCCC Cancer and Stem Cell Biology Program Area
Research Interests
We are a group of scientists in the Department of Molecular, Cell and Developmental Biology at UCLA. We use zebrafish to investigate the molecular mechanisms by which diverse and specialized cell types are developed during vertebrate embryogenesis. Our main interests include studying hematopoietic and vascular development, and pancreas organogenesis. We also use zebrafish to model human diseases and facilitate the identification of therapeutic agents. Chemical biology coupled with zebrafish genetics has been used in our laboratory to identify and develop small molecule candidates with the potential to treat cancers. To better advance zebrafish as a model organism for the research community, we are undertaking genome-wide mutagenesis with retroviral insertions and large-scale transgenic reporter gene expression for tissue specific genes by using GFP/RFP enhancer traps and BAC transgenesis. To learn more about our research program, please visit our lab home page at http://www.mcdb.ucla.edu/Research/ShuoLin/.
Biography
Shuo Lin is a developmental biologist and geneticist who has served on the UCLA College of Life Science faculty since he joined the Department of Molecular, Cell and Developmental Biology in 2001. He became a full professor in 2003. Prior to joining UCLA he was a faculty member at Medical College of Georgia. Dr. Lin earned his Ph.D. in Biological Chemistry at Boston University School of Medicine in 1991. He was a postdoctoral fellow in Nancy Hopkins? laboratory at the Massachusetts Institute of Technology from 1991-1995, where he worked on genetic studies of zebrafish. Dr. Lin is actively involved in graduate education and biomedical research. His laboratory research centers on genetics of hematopoietic/vascular development and organogenesis.
Publications
A selected list of publications:
- Saji George, Sijie Lin, Zhaoxia Ji, Courtney R. Thomas, LinJiang L, Mathew Mecklenburg, Huan Meng, Xiang Wang, Haiyuan Zhang, Tian Xia, J. Nathan Hohman, Shuo Lin, Jeffrey I. Zink, Paul S. Weiss, and André E. Nel Surface Defects on Plate-Shaped Silver Nanoparticles Contribute to Its Hazard Potential in a Fish Gill Cell Line and Zebrafish Embryos ACS Nano, 2012; 6(5): 3745-3759.
- Xia T, Zhao Y, Sager T, George S, Pokhrel S, Li N, Schoenfeld D, Meng H, Lin S, Wang X, Wang M, Ji Z, Zink JI, Mädler L, Castranova V, Lin S, Nel AE Decreased Dissolution of ZnO by Iron Doping Yields Nanoparticles with Reduced Toxicity in the Rodent Lung and Zebrafish Embryos ACS Nano, 2011; 5(2): 1223-1235.
- George S, Xia T, Rallo R, Zhao Y, Ji Z, Lin S, Wang X, Zhang H, France B, Schoenfeld D, Damoiseaux R, Liu R, Lin S, Bradley KA, Cohen Y, Nel AE Use of a High-Throughput Screening Approach Coupled with In Vivo Zebrafish Embryo Screening To Develop Hazard Ranking for Engineered Nanomaterials ACS Nano, 2011; Epub ahead of print: .
- Jagadeeswaran P, Lin S, Weinstein B, Hutson A, Kim S Loss of GATA1 and gain of FLI1 expression during thrombocyte maturation Blood Cells Mol Dis, 2010; 44(3): 175-80.
- Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, Zon LI TIF1gamma controls erythroid cell fate by regulating transcription elongation Cell, 2010; 142(1): 133-43.
- Powers JW, Mazilu JK, Lin S, McCabe ER The effects of hyperglycemia on adrenal cortex function and steroidogenesis in the zebrafish Mol Genet Metab, 2010; 101(4): 421-2.
- Mazilu JK, Powers JW, Lin S, McCabe ER ff1b, the SF1 ortholog, is important for pancreatic islet cell development in zebrafish Mol Genet Metab, 2010; 101(4): 391-4.
- Yang H, Xiang J, Wang N, Zhao Y, Hyman J, Li S, Jiang J, Chen JK, Yang Z, Lin S Converse conformational control of smoothened activity by structurally related small molecules J Biol Chem, 2009; 284(31): 20876-84.
- Gomez GA, Veldman MB, Zhao Y, Burgess S, Lin S Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish PLoS One, 2009; 43(3): e4994.
- Bukrinsky A, Griffin KJ, Zhao Y, Lin S, Banerjee U Essential role of spi-1-like (spi-1l) in zebrafish myeloid cell differentiation Blood, 2009; 113(9): 2038-46.
- Xiang J, Yang H, Che C, Zou H, Yang H, Wei Y, Quan J, Zhang H, Yang Z, Lin S Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays PLoS One, 2009; 4(2): e4361.
- Lee D, Park C, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez G, Kyba M, Lin S, Janknecht R, Lim DS and Choi K ER71 acts downstream of BMP, Notch and Wnt signaling in blood and vessel progenitor specification Cell Stem Cell, 2008; 2(5): 497-507.
- Jiang Z, Song J, Qi F, Xiao A, An X, Liu NA, Zhu Z, Zhang B, Lin S Exdpf is a key regulator of exocrine pancreas development controlled by retinoic acid and ptf1a in zebrafish PLoS Biol, 2008; 6(11): e293.
- Wei W, Wen L, Huang P, Zhang Z, Chen Y, Xiao A, Huang H, Zhu Z, Zhang B, Lin S Gfi1.1 regulates hematopoietic lineage differentiation during zebrafish embryogenesis Cell Res, 2008; 18(6): 677-85.
- Liu NA, Ren M, Song J, Ríos Y, Wawrowsky K, Ben-Shlomo A, Lin S, Melmed S In vivo time-lapse imaging delineates the zebrafish pituitary proopiomelanocortin lineage boundary regulated by FGF3 signal Dev Biol, 2008; 319(2): Dev Biol..
- Sumanas S, Gomez G, Zhao Y, Park C, Choi K, and Lin S Interplay between Etsrp/ER71, scl and alk8 signaling controls endothelial and myeloid cell formation Blood, 2008; 111(9): 4500-10.
- Danilova N, Sakamoto KM, Lin S Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family Blood, 2008; 112(13): 5228-37.
- Yang Z, Jiang H, Zhao F, Shankar D, Sakamoto KM, Zhang MQ, and Lin S A highly conserved regulatory element controls hematopoietic expression of GATA-2 in zebrafish BMC Dev Biol, 2007; 7(1): 97.
- Wang D, Jao LE, Zheng N, Dolan K, Ivey J, Zonies S, Wu X, Wu K, Yang H, Meng Q, Zhu Z, Zhang B, Lin S, and Burgess SM Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions Proc Natl Acad Sci U S A, 2007; 104(3): 12428-33.
- Song J, Kim HJ, Gong Z, Liu NA, and Lin S. Vhnf1 acts downstream of Bmp, Fgf, and RA signals to regulate endocrine beta cell development in zebrafish Dev Biol, 2007; 303(2): 561-75.
- Zhong, H. Wu, X. Huang, H. Fan, Q. Zhu, Z. Lin, S. Vertebrate MAX-1 is required for vascular patterning in zebrafish Proc Natl Acad Sci U S A, 2006; 103(45): 16800-5.
- Liu, B. Lee, K. W. Anzo, M. Zhang, B. Zi, X. Tao, Y. Shiry, L. Pollak, M. Lin, S. Cohen, P. Insulin-like growth factor-binding protein-3 inhibition of prostate cancer growth involves suppression of angiogenesis Oncogene, 2006; .
- Sumanas, S. Lin, S. Ets1-related protein is a key regulator of vasculogenesis in zebrafish PLoS Biol, 2006; 4(1): e10.
- Kim, H. J. Sumanas, S. Palencia-Desai, S. Dong, Y. Chen, J. N. Lin, S. Genetic analysis of early endocrine pancreas formation in zebrafish Mol Endocrinol, 2006; 20(1): 194-203.
- Yang, Z. Jiang, H. Chachainasakul, T. Gong, S. Yang, X. W. Heintz, N. Lin, S. Modified bacterial artificial chromosomes for zebrafish transgenesis Methods, 2006; 39(3): 183-8.
- Wu, X. Zhong, H. Song, J. Damoiseaux, R. Yang, Z. Lin, S. Mycophenolic acid is a potent inhibitor of angiogenesis Arterioscler Thromb Vasc Biol, 2006; 26(10): 2414-6.
- Liu, N. A. Liu, Q. Wawrowsky, K. Yang, Z. Lin, S. Melmed, S. Prolactin receptor signaling mediates the osmotic response of embryonic zebrafish lactotrophs Mol Endocrinol, 2006; 20(4): 871-80.
- Kwan, T. T. Liang, R. Verfaillie, C. M. Ekker, S. C. Chan, L. C. Lin, S. Leung, A. Y. Regulation of primitive hematopoiesis in zebrafish embryos by the death receptor gene Exp Hematol, 2006; 34(1): 27-34.
- Zhao, Y. Yang, Z. Phelan, J. K. Wheeler, D. A. Lin, S. McCabe, E. R. B. Zebrafish dax1 is required for development of the interrenal organ, the adrenal cortex equivalent Molecular Endocrinology, 2006; 20(11): 2630-2640.
- Wan, H. Korzh, S. Li, Z. Mudumana, S. P. Korzh, V. Jiang, Y. J. Lin, S. Gong, Z. Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoter Exp Cell Res, 2006; 312(9): 1526-39.
- Sumanas, S. Jorniak, T. Lin, S. Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants Blood, 2005; 106(2): 534-41.
- Sumanas, S. Zhang, B. Dai, R. Lin, S. 15-zinc finger protein Bloody Fingers is required for zebrafish morphogenetic movements during neurulation Dev Biol, 2005; 283(1): 85-96.
- Huang, H. Zhang, B. Hartenstein, P. A. Chen, J. N. Lin, S. NXT2 is required for embryonic heart development in zebrafish BMC Dev Biol, 2005; 5(1): 7.
- Kim, H. J. Schleiffarth, J. R. Jessurun, J. Sumanas, S. Petryk, A. Lin, S. Ekker, S. C. Wnt5 signaling in vertebrate pancreas development BMC Biol, 2005; 3: 23.
- Penberthy, W. T. Zhao, C. Zhang, Y. Jessen, J. R. Yang, Z. Bricaud, O. Collazo, A. Meng, A. Lin, S. Pur alpha and Sp8 as opposing regulators of neural gata2 expression Dev Biol, 2004; 275(1): 225-34.
- Ju, B. Huang, H. Lee, K. Y. Lin, S. Cloning zebrafish by nuclear transfer Methods Cell Biol, 2004; 77: 403-11.
- Shafizadeh, E. Peterson, R. T. Lin, S. Induction of reversible hemolytic anemia in living zebrafish using a novel small molecule Comp Biochem Physiol C Toxicol Pharmacol, 2004; 138(3): 245-9.
- Pi, W. Yang, Z. Wang, J. Ruan, L. Yu, X. Ling, J. Krantz, S. Isales, C. Conway, S. J. Lin, S. Tuan, D. The LTR enhancer of ERV-9 human endogenous retrovirus is active in oocytes and progenitor cells in transgenic zebrafish and humans Proc Natl Acad Sci U S A, 2004; 101(3): 805-10.
- Liu, N. A. Huang, H. Yang, Z. Herzog, W. Hammerschmidt, M. Lin, S. Melmed, S. Pituitary corticotroph ontogeny and regulation in transgenic zebrafish Mol Endocrinol, 2003; 17(5): 959-66.
- Traver, D. Paw, B. H. Poss, K. D. Penberthy, W. T. Lin, S. Zon, L. I. Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants Nat Immunol, 2003; 4(12): 1238-46.
- Cross, L. M. Cook, M. A. Lin, S. Chen, J. N. Rubinstein, A. L. Rapid analysis of angiogenesis drugs in a live fluorescent zebrafish assay Arterioscler Thromb Vasc Biol, 2003; 23(5): 911-2.
- Brownlie, A. Hersey, C. Oates, A. C. Paw, B. H. Falick, A. M. Witkowska, H. E. Flint, J. Higgs, D. Jessen, J. Bahary, N. Zhu, H. Lin, S. Zon, L. Characterization of embryonic globin genes of the zebrafish Dev Biol, 2003; 255(1): 48-61.
- Zeller, J. Schneider, V. Malayaman, S. Higashijima, S. Okamoto, H. Gui, J. Lin, S. Granato, M. Migration of zebrafish spinal motor nerves into the periphery requires multiple myotome-derived cues Dev Biol, 2002; 252(2): 241-56.
- Shafizadeh, E. Paw, B. H. Foott, H. Liao, E. C. Barut, B. A. Cope, J. J. Zon, L. I. Lin, S. Characterization of zebrafish merlot/chablis as non-mammalian vertebrate models for severe congenital anemia due to protein 4.1 deficiency Development, 2002; 129(18): 4359-70.
- Lee, K. Y. Huang, H. Ju, B. Yang, Z. Lin, S. Cloned zebrafish by nuclear transfer from long-term-cultured cells Nat Biotechnol, 2002; 20(8): 795-9.
- Shafizadeh, E. Huang, H. Lin, S. Transgenic zebrafish expressing green fluorescent protein Methods Mol Biol, 2002; 183: 225-33.
- Penberthy, W. T. Shafizadeh, E. Lin, S. The zebrafish as a model for human disease Front Biosci, 2002; 7: d1439-53.
- Huang, H. Liu, N. Lin, S. Pdx-1 knockdown reduces insulin promoter activity in zebrafish Genesis, 2001; 30(3): 134-6.
- Huang, H. Vogel, S. S. Liu, N. Melton, D. A. Lin, S. Analysis of pancreatic development in living transgenic zebrafish embryos Mol Cell Endocrinol, 2001; 177(1-2): 117-24.
- Yang, Z. Liu, N. Lin, S. A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression Dev Biol, 2001; 231(1): 138-48.
- Long, Q. Huang, H. Shafizadeh, E. Liu, N. Lin, S. Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish Nat Cell Biol, 2000; 2(8): 549-52.
- Lin, S. Transgenic zebrafish Methods Mol Biol, 2000; 136: 375-83.
- Meng, A. Moore, B. Tang, H. Yuan, B. Lin, S. A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates Development, 1999; 126(6): 1259-68.
- Jessen, J. R. Willett, C. E. Lin, S. Artificial chromosome transgenesis reveals long-distance negative regulation of rag1 in zebrafish Nat Genet, 1999; 23(1): 15-6.
- Meng, A. Jessen, J. R. Lin, S. Transgenesis Methods Cell Biol, 1999; 60: 133-48.
- Meng, A. Tang, H. Yuan, B. Ong, B. A. Long, Q. Lin, S. Positive and negative cis-acting elements are required for hematopoietic expression of zebrafish GATA-1 Blood, 1999; 93(2): 500-8.
- Wang, H. Long, Q. Marty, S. D. Sassa, S. Lin, S. A zebrafish model for hepatoerythropoietic porphyria Nat Genet, 1998; 20(3): 239-43.
- Jessen, J. R. Meng, A. McFarlane, R. J. Paw, B. H. Zon, L. I. Smith, G. R. Lin, S. Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis Proc Natl Acad Sci U S A, 1998; 95(9): 5121-6.
- Long, Q. Meng, A. Wang, H. Jessen, J. R. Farrell, M. J. Lin, S. GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene Development, 1997; 124(20): 4105-11.
- Meng, A. Tang, H. Ong, B. A. Farrell, M. J. Lin, S. Promoter analysis in living zebrafish embryos identifies a cis-acting motif required for neuronal expression of GATA-2 Proc Natl Acad Sci U S A, 1997; 94(12): 6267-72.
- Lin, S. Gaiano, N. Culp, P. Burns, J. C. Friedmann, T. Yee, J. K. Hopkins, N. Integration and germ-line transmission of a pseudotyped retroviral vector in zebrafish Science, 1994; 265(5172): 666-9.
- Lin, S. Long, W. Chen, J. Hopkins, N. Production of germ-line chimeras in zebrafish by cell transplants from genetically pigmented to albino embryos Proc Natl Acad Sci U S A, 1992; 89(10): 4519-23.