Jerome Zack*

Jerome A Zack

Department Chair, MIMG, University of California Los Angeles

Professor, Medicine, University of California Los Angeles

Professor, MIMG, University of California Los Angeles

UC Profile

Jerome Zack, Ph.D., holds the M. Philip Davis Chair in Microbiology and Immunology. The Zack laboratory at UCLA is exploring ways to purge HIV reservoirs to effect either a cure or “functional cure” (long term remission) of HIV disease. It is long lived latent reservoirs that mandate that HIV infected individuals remain on antiretroviral therapy, because upon cessation of therapy, latent reservoirs rekindle virus replication and disease progression. The Zack laboratory is exploring “kick and kill” and immune system engineering to accomplish their goals. The kick and kill approach involves activation of infected cells to allow visualization of viral proteins, while the individual is on therapy to prevent spread of virus. Subsequently an anti-viral targeting approach is added, to kill the previously latently infected cell, which is now expressing viral proteins. Targeting approaches being pursued include cell-based effectors such as engineered CTL or NK cells. A recent study along these lines showed that a PKC modulator (kick) coupled with NK cells as the “kill” component, could decrease HIV reservoirs in a humanized mouse model. The genetic engineering approach involves introduction of anti-HIV chimeric antigen receptors (CARs) into human hematopoietic progenitor cells. These cells then develop into effector cells in vivo (T and NK cells), which can now target HIV infected cells. This approach has shown some efficacy in humanized mice and non-human primates. Much of Dr. Zack’s work involves the use of humanized mice, a tool which can be extended to other viral systems.

Interests

Immunology, Virology, Gene Therapy, HIV Pathogenesis

Education and Training

UT Health Science CenterPhD1987Immunology
Cal State Long BeachMS1980Med Microbiology
UC IrvineBS1976Biology

Awards and Honors

  • Distinguished Alumnus, CSULB College of Natural Sciences and Mathematics, 2011.
  • Distinguished Research Career Award, Ohio State Univ, 2000.
  • NIH Merit Award, NIH/NIAID, 1998.
  • Elizabeth Glazer Scientist Award, Pediatric AIDS Foundation, 1996-2001.

Publications

  1. Kim JT, Bresson-Tan G, Zack JA. Current Advances in Humanized Mouse Models for Studying NK Cells and HIV Infection.. Microorganisms, 2023.
  2. Moran JA, Ranjan A, Hourani R, Kim JT, Wender PA, Zack JA, Marsden MD. Secreted factors induced by PKC modulators do not indirectly cause HIV latency reversal.. Virology, 2023.
  3. Kim JT, Zack JA. A humanized mouse model to study NK cell biology during HIV infection.. The Journal of clinical investigation, 2022.
  4. Kim JT, Zhang TH, Carmona C, Lee B, Seet CS, Kostelny M, Shah N, Chen H, Farrell K, Soliman MSA, Dimapasoc M, Sinani M, Blanco KYR, Bojorquez D, Jiang H, Shi Y, Du Y, Komarova NL, Wodarz D, Wender PA, Marsden MD, Sun R, Zack JA. Latency reversal plus natural killer cells diminish HIV reservoir in vivo.. Nature communications, 2022.
  5. Zhen A, Carrillo MA, Mu W, Rezek V, Martin H, Hamid P, Chen ISY, Yang OO, Zack JA, Kitchen SG. Correction: Robust CAR-T memory formation and function via hematopoietic stem cell delivery.. PLoS pathogens, 2021.
  6. Zhen A, Carrillo MA, Mu W, Rezek V, Martin H, Hamid P, Chen ISY, Yang OO, Zack JA, Kitchen SG. Robust CAR-T memory formation and function via hematopoietic stem cell delivery.. PLoS pathogens, 2021.
  7. Barber-Axthelm IM, Barber-Axthelm V, Sze KY, Zhen A, Suryawanshi GW, Chen IS, Zack JA, Kitchen SG, Kiem HP, Peterson CW. Stem cell-derived CAR T cells traffic to HIV reservoirs in macaques.. JCI insight, 2021.
  8. Marsden MD, Zhang TH, Du Y, Dimapasoc M, Soliman MSA, Wu X, Kim JT, Shimizu A, Schrier A, Wender PA, Sun R, Zack JA. Tracking HIV Rebound following Latency Reversal Using Barcoded HIV.. Cell reports. Medicine, 2020.
  9. Pache L, Marsden MD, Teriete P, Portillo AJ, Heimann D, Kim JT, Soliman MSA, Dimapasoc M, Carmona C, Celeridad M, Spivak AM, Planelles V, Cosford NDP, Zack JA, Chanda SK. Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo.. Cell reports. Medicine, 2020.
  10. Sloane JL, Benner NL, Keenan KN, Zang X, Soliman MSA, Wu X, Dimapasoc M, Chun TW, Marsden MD, Zack JA, Wender PA. Prodrugs of PKC modulators show enhanced HIV latency reversal and an expanded therapeutic window.. Proceedings of the National Academy of Sciences of the United States of America, 2020.
  11. Hardman C, Ho S, Shimizu A, Luu-Nguyen Q, Sloane JL, Soliman MSA, Marsden MD, Zack JA, Wender PA. Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy.. Nature communications, 2020.
  12. Galli V, Nixon CC, Strbo N, Artesi M, de Castro-Amarante MF, McKinnon K, Fujikawa D, Omsland M, Washington-Parks R, Romero L, Caruso B, Durkin K, Brown S, Karim B, Vaccari M, Jacobson S, Zack JA, Van den Broeke A, Pise-Masison C, Franchini G. Essential Role of Human T Cell Leukemia Virus Type 1 orf-I in Lethal Proliferation of CD4+ Cells in Humanized Mice.. Journal of virology, 2019.
  13. Zhu Y, Smith DJ, Zhou Y, Li YR, Yu J, Lee D, Wang YC, Di Biase S, Wang X, Hardoy C, Ku J, Tsao T, Lin LJ, Pham AT, Moon H, McLaughlin J, Cheng D, Hollis RP, Campo-Fernandez B, Urbinati F, Wei L, Pang L, Rezek V, Berent-Maoz B, Macabali MH, Gjertson D, Wang X, Galic Z, Kitchen SG, An DS, Hu-Lieskovan S, Kaplan-Lefko PJ, De Oliveira SN, Seet CS, Larson SM, Forman SJ, Heath JR, Zack JA, Crooks GM, Radu CG, Ribas A, Kohn DB, Witte ON, Yang L. Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.. Cell stem cell, 2019.
  14. Llewellyn GN, Seclén E, Wietgrefe S, Liu S, Chateau M, Pei H, Perkey K, Marsden MD, Hinkley SJ, Paschon DE, Holmes MC, Zack JA, Louie SG, Haase AT, Cannon PM. Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1+ and TIGIT+ CD4 T Cells.. Journal of virology, 2019.
  15. Hazim RA, Karumbayaram S, Jiang M, Dimashkie A, Lopes VS, Li D, Burgess BL, Vijayaraj P, Alva-Ornelas JA, Zack JA, Kohn DB, Gomperts BN, Pyle AD, Lowry WE, Williams DS. Correction to: Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization.. Stem cell research & therapy, 2019.
  16. Marsden MD, Wu X, Navab SM, Loy BA, Schrier AJ, DeChristopher BA, Shimizu AJ, Hardman CT, Ho S, Ramirez CM, Wender PA, Zack JA. Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents.. Virology, 2018.
  17. Zhen A, Peterson CW, Carrillo MA, Reddy SS, Youn CS, Lam BB, Chang NY, Martin HA, Rick JW, Kim J, Neel NC, Rezek VK, Kamata M, Chen ISY, Zack JA, Kiem HP, Kitchen SG. Correction: Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS.. PLoS pathogens, 2018.
  18. Zhen A, Peterson CW, Carrillo MA, Reddy SS, Youn CS, Lam BB, Chang NY, Martin HA, Rick JW, Kim J, Neel NC, Rezek VK, Kamata M, Chen ISY, Zack JA, Kiem HP, Kitchen SG. Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS.. PLoS pathogens, 2017.
  19. Hazim RA, Karumbayaram S, Jiang M, Dimashkie A, Lopes VS, Li D, Burgess BL, Vijayaraj P, Alva-Ornelas JA, Zack JA, Kohn DB, Gomperts BN, Pyle AD, Lowry WE, Williams DS. Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization.. Stem cell research & therapy, 2017.
  20. Marsden MD, Loy BA, Wu X, Ramirez CM, Schrier AJ, Murray D, Shimizu A, Ryckbosch SM, Near KE, Chun TW, Wender PA, Zack JA. In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication.. PLoS pathogens, 2017.
  21. Marsden MD, Zack JA. Humanized Mouse Models for Human Immunodeficiency Virus Infection.. Annual review of virology, 2017.
  22. Carrillo MA, Zhen A, Zack JA, Kitchen SG. New approaches for the enhancement of chimeric antigen receptors for the treatment of HIV.. Translational research : the journal of laboratory and clinical medicine, 2017.
  23. Kitchen SG, Zack JA. Engineering HIV-Specific Immunity with Chimeric Antigen Receptors.. AIDS patient care and STDs, 2016.
  24. Smith DJ, Lin LJ, Moon H, Pham AT, Wang X, Liu S, Ji S, Rezek V, Shimizu S, Ruiz M, Lam J, Janzen DM, Memarzadeh S, Kohn DB, Zack JA, Kitchen SG, An DS, Yang L. Propagating Humanized BLT Mice for the Study of Human Immunology and Immunotherapy.. Stem cells and development, 2016.
  25. Ali A, Kitchen SG, Chen ISY, Ng HL, Zack JA, Yang OO. HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies.. Journal of virology, 2016.
  26. Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F, International AIDS Society Towards a Cure Working Group, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J. International AIDS Society global scientific strategy: towards an HIV cure 2016.. Nature medicine, 2016.
  27. Zhen A, Rezek V, Youn C, Rick J, Lam B, Chang N, Zack J, Kamata M, Kitchen S. Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model.. Journal of visualized experiments : JoVE, 2016.
  28. Dou DR, Calvanese V, Sierra MI, Nguyen AT, Minasian A, Saarikoski P, Sasidharan R, Ramirez CM, Zack JA, Crooks GM, Galic Z, Mikkola HK. Medial HOXA genes demarcate haematopoietic stem cell fate during human development.. Nature cell biology, 2016.
  29. Young CS, Hicks MR, Ermolova NV, Nakano H, Jan M, Younesi S, Karumbayaram S, Kumagai-Cresse C, Wang D, Zack JA, Kohn DB, Nakano A, Nelson SF, Miceli MC, Spencer MJ, Pyle AD. A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells.. Cell stem cell, 2016.
  30. Akkina R, Allam A, Balazs AB, Blankson JN, Burnett JC, Casares S, Garcia JV, Hasenkrug KJ, Kashanchi F, Kitchen SG, Klein F, Kumar P, Luster AD, Poluektova LY, Rao M, Sanders-Beer BE, Shultz LD, Zack JA. Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.. AIDS research and human retroviruses, 2016.
  31. Sanchez DJ, Miranda D, Marsden MD, Dizon TM, Bontemps JR, Davila SJ, Del Mundo LE, Ha T, Senaati A, Zack JA, Cheng G. Disruption of Type I Interferon Induction by HIV Infection of T Cells.. PloS one, 2015.
  32. Nixon CC, Schwartz BH, Dixit D, Zack JA, Vatakis DN. Corrigendum: Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor.. Scientific reports, 2015.
  33. Kim SG, Lowe EL, Dixit D, Youn CS, Kim IJ, Jung JB, Rovner R, Zack JA, Vatakis DN. Cocaine-mediated impact on HIV infection in humanized BLT mice.. Scientific reports, 2015.
  34. Zhen A, Kamata M, Rezek V, Rick J, Levin B, Kasparian S, Chen IS, Yang OO, Zack JA, Kitchen SG. HIV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells.. Molecular therapy : the journal of the American Society of Gene Therapy, 2015.
  35. McCracken MN, Vatakis DN, Dixit D, McLaughlin J, Zack JA, Witte ON. Noninvasive detection of tumor-infiltrating T cells by PET reporter imaging.. The Journal of clinical investigation, 2015.
  36. Menon T, Firth AL, Scripture-Adams DD, Galic Z, Qualls SJ, Gilmore WB, Ke E, Singer O, Anderson LS, Bornzin AR, Alexander IE, Zack JA, Verma IM. Lymphoid regeneration from gene-corrected SCID-X1 subject-derived iPSCs.. Cell stem cell, 2015.
  37. Nixon CC, Schwartz BH, Dixit D, Zack JA, Vatakis DN. Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor [corrected].. Scientific reports, 2015.
  38. Shimizu S, Ringpis GE, Marsden MD, Cortado RV, Wilhalme HM, Elashoff D, Zack JA, Chen IS, An DS. RNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice.. Molecular therapy. Nucleic acids, 2015.
  39. Marsden MD, Zack JA. Double trouble: HIV latency and CTL escape.. Cell host & microbe, 2015.
  40. Marsden MD, Zack JA. Studies of retroviral infection in humanized mice.. Virology, 2015.
  41. Marsden MD, Zack JA. Experimental Approaches for Eliminating Latent HIV.. Forum on immunopathological diseases and therapeutics, 2015.
  42. Marsden MD, Zack JA. Neutralizing the HIV reservoir.. Cell, 2014.
  43. Buehler DC, Marsden MD, Shen S, Toso DB, Wu X, Loo JA, Zhou ZH, Kickhoefer VA, Wender PA, Zack JA, Rome LH. Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug delivery.. ACS nano, 2014.
  44. Zhen A, Krutzik SR, Levin BR, Kasparian S, Zack JA, Kitchen SG. CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection.. Journal of virology, 2014.
  45. Chodon T, Comin-Anduix B, Chmielowski B, Koya RC, Wu Z, Auerbach M, Ng C, Avramis E, Seja E, Villanueva A, McCannel TA, Ishiyama A, Czernin J, Radu CG, Wang X, Gjertson DW, Cochran AJ, Cornetta K, Wong DJ, Kaplan-Lefko P, Hamid O, Samlowski W, Cohen PA, Daniels GA, Mukherji B, Yang L, Zack JA, Kohn DB, Heath JR, Glaspy JA, Witte ON, Baltimore D, Economou JS, Ribas A. Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma.. Clinical cancer research : an official journal of the American Association for Cancer Research, 2014.
  46. Awe JP, Lee PC, Ramathal C, Vega-Crespo A, Durruthy-Durruthy J, Cooper A, Karumbayaram S, Lowry WE, Clark AT, Zack JA, Sebastiano V, Kohn DB, Pyle AD, Martin MG, Lipshutz GS, Phelps PE, Pera RA, Byrne JA. Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status.. Stem cell research & therapy, 2013.
  47. Nixon CC, Vatakis DN, Reichelderfer SN, Dixit D, Kim SG, Uittenbogaart CH, Zack JA. HIV-1 infection of hematopoietic progenitor cells in vivo in humanized mice.. Blood, 2013.
  48. Kim SG, Jung JB, Dixit D, Rovner R, Zack JA, Baldwin GC, Vatakis DN. Cocaine exposure enhances permissiveness of quiescent T cells to HIV infection.. Journal of leukocyte biology, 2013.
  49. Beans EJ, Fournogerakis D, Gauntlett C, Heumann LV, Kramer R, Marsden MD, Murray D, Chun TW, Zack JA, Wender PA. Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo.. Proceedings of the National Academy of Sciences of the United States of America, 2013.
  50. Marsden MD, Zack JA. HIV/AIDS eradication.. Bioorganic & medicinal chemistry letters, 2013.
  51. Zack JA, Kim SG, Vatakis DN. HIV restriction in quiescent CD4⁺ T cells.. Retrovirology, 2013.
  52. Vatakis DN, Arumugam B, Kim SG, Bristol G, Yang O, Zack JA. Introduction of exogenous T-cell receptors into human hematopoietic progenitors results in exclusion of endogenous T-cell receptor expression.. Molecular therapy : the journal of the American Society of Gene Therapy, 2013.
  53. Liu SY, Aliyari R, Chikere K, Li G, Marsden MD, Smith JK, Pernet O, Guo H, Nusbaum R, Zack JA, Freiberg AN, Su L, Lee B, Cheng G. Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol.. Immunity, 2012.
  54. Vatakis DN, Bristol GC, Kim SG, Levin B, Liu W, Radu CG, Kitchen SG, Zack JA. Using the BLT humanized mouse as a stem cell based gene therapy tumor model.. Journal of visualized experiments : JoVE, 2012.
  55. Marsden MD, Krogstad PA, Zack JA. Virological evidence supporting the use of raltegravir in HIV post-exposure prophylaxis regimens.. Antiviral therapy, 2012.
  56. DeChristopher BA, Loy BA, Marsden MD, Schrier AJ, Zack JA, Wender PA. Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro.. Nature chemistry, 2012.
  57. Kitchen SG, Levin BR, Bristol G, Rezek V, Kim S, Aguilera-Sandoval C, Balamurugan A, Yang OO, Zack JA. In vivo suppression of HIV by antigen specific T cells derived from engineered hematopoietic stem cells.. PLoS pathogens, 2012.
  58. Karumbayaram S, Lee P, Azghadi SF, Cooper AR, Patterson M, Kohn DB, Pyle A, Clark A, Byrne J, Zack JA, Plath K, Lowry WE. From skin biopsy to neurons through a pluripotent intermediate under Good Manufacturing Practice protocols.. Stem cells translational medicine, 2011.
  59. Vatakis DN, Koya RC, Nixon CC, Wei L, Kim SG, Avancena P, Bristol G, Baltimore D, Kohn DB, Ribas A, Radu CG, Galic Z, Zack JA. Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells.. Proceedings of the National Academy of Sciences of the United States of America, 2011.
  60. Marsden MD, Kovochich M, Suree N, Shimizu S, Mehta R, Cortado R, Bristol G, An DS, Zack JA. HIV latency in the humanized BLT mouse.. Journal of virology, 2011.
  61. Marban C, Su T, Ferrari R, Li B, Vatakis D, Pellegrini M, Zack JA, Rohr O, Kurdistani SK. Genome-wide binding map of the HIV-1 Tat protein to the human genome.. PloS one, 2011.
  62. Marsden MD, Burke BP, Zack JA. HIV latency is influenced by regions of the viral genome outside of the long terminal repeats and regulatory genes.. Virology, 2011.
  63. Mitsuyasu RT, Zack JA, Macpherson JL, Symonds GP. Phase I/II Clinical Trials Using Gene-Modified Adult Hematopoietic Stem Cells for HIV: Lessons Learnt.. Stem cells international, 2011.
  64. Marsden MD, Avancena P, Kitchen CM, Hubbard T, Zack JA. Single mutations in HIV integrase confer high-level resistance to raltegravir in primary human macrophages.. Antimicrobial agents and chemotherapy, 2011.
  65. Kovochich M, Marsden MD, Zack JA. Activation of latent HIV using drug-loaded nanoparticles.. PloS one, 2011.
  66. Kitchen SG, Zack JA. Stem cell-based approaches to treating HIV infection.. Current opinion in HIV and AIDS, 2011.
  67. Vatakis DN, Nixon CC, Zack JA. Quiescent T cells and HIV: an unresolved relationship.. Immunologic research, 2010.
  68. Tchieu J, Kuoy E, Chin MH, Trinh H, Patterson M, Sherman SP, Aimiuwu O, Lindgren A, Hakimian S, Zack JA, Clark AT, Pyle AD, Lowry WE, Plath K. Female human iPSCs retain an inactive X chromosome.. Cell stem cell, 2010.
  69. Epeldegui M, Thapa DR, De la Cruz J, Kitchen S, Zack JA, Martínez-Maza O. CD40 ligand (CD154) incorporated into HIV virions induces activation-induced cytidine deaminase (AID) expression in human B lymphocytes.. PloS one, 2010.
  70. Brown HJ, Peng L, Harada JN, Walker JR, Cole S, Lin SF, Zack JA, Chanda SK, Sun R. Gene expression and transcription factor profiling reveal inhibition of transcription factor cAMP-response element-binding protein by gamma-herpesvirus replication and transcription activator.. The Journal of biological chemistry, 2010.
  71. Sundaravaradan V, Mehta R, Harris DT, Zack JA, Ahmad N. Differential expression and interaction of host factors augment HIV-1 gene expression in neonatal mononuclear cells.. Virology, 2010.
  72. Marsden MD, Zack JA. Establishment and maintenance of HIV latency: model systems and opportunities for intervention.. Future virology, 2010.
  73. Shimizu S, Hong P, Arumugam B, Pokomo L, Boyer J, Koizumi N, Kittipongdaja P, Chen A, Bristol G, Galic Z, Zack JA, Yang O, Chen IS, Lee B, An DS. A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model.. Blood, 2009.
  74. Kitchen SG, Bennett M, Galic Z, Kim J, Xu Q, Young A, Lieberman A, Joseph A, Goldstein H, Ng H, Yang O, Zack JA. Engineering antigen-specific T cells from genetically modified human hematopoietic stem cells in immunodeficient mice.. PloS one, 2009.
  75. Vatakis DN, Kim S, Kim N, Chow SA, Zack JA. Human immunodeficiency virus integration efficiency and site selection in quiescent CD4+ T cells.. Journal of virology, 2009.
  76. Bernstein HB, Wang G, Plasterer MC, Zack JA, Ramasastry P, Mumenthaler SM, Kitchen CM. CD4+ NK cells can be productively infected with HIV, leading to downregulation of CD4 expression and changes in function.. Virology, 2009.
  77. Mitsuyasu RT, Merigan TC, Carr A, Zack JA, Winters MA, Workman C, Bloch M, Lalezari J, Becker S, Thornton L, Akil B, Khanlou H, Finlayson R, McFarlane R, Smith DE, Garsia R, Ma D, Law M, Murray JM, von Kalle C, Ely JA, Patino SM, Knop AE, Wong P, Todd AV, Haughton M, Fuery C, Macpherson JL, Symonds GP, Evans LA, Pond SM, Cooper DA. Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells.. Nature medicine, 2009.
  78. Vatakis DN, Nixon CC, Bristol G, Zack JA. Differentially stimulated CD4+ T cells display altered human immunodeficiency virus infection kinetics: implications for the efficacy of antiviral agents.. Journal of virology, 2009.
  79. Conway AE, Lindgren A, Galic Z, Pyle AD, Wu H, Zack JA, Pelligrini M, Teitell MA, Clark AT. A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors.. Stem cells (Dayton, Ohio), 2009.
  80. Galic Z, Kitchen SG, Subramanian A, Bristol G, Marsden MD, Balamurugan A, Kacena A, Yang O, Zack JA. Generation of T lineage cells from human embryonic stem cells in a feeder free system.. Stem cells (Dayton, Ohio), 2009.
  81. Subramanian A, Guo B, Marsden MD, Galic Z, Kitchen S, Kacena A, Brown HJ, Cheng G, Zack JA. Macrophage differentiation from embryoid bodies derived from human embryonic stem cells.. Journal of stem cells, 2009.
  82. Miranda-Carboni GA, Krum SA, Yee K, Nava M, Deng QE, Pervin S, Collado-Hidalgo A, Galic Z, Zack JA, Nakayama K, Nakayama KI, Lane TF. A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors.. Genes & development, 2008.
  83. Marsden MD, Zack JA. Eradication of HIV: current challenges and new directions.. The Journal of antimicrobial chemotherapy, 2008.
  84. Marsden MD, Xu J, Hamer D, Zack JA. Short communication: Activating stimuli enhance immunotoxin-mediated killing of HIV-infected macrophages.. AIDS research and human retroviruses, 2008.
  85. Burke B, Brown HJ, Marsden MD, Bristol G, Vatakis DN, Zack JA. Primary cell model for activation-inducible human immunodeficiency virus.. Journal of virology, 2007.
  86. Marsden MD, Zack JA. Human immunodeficiency virus bearing a disrupted central DNA flap is pathogenic in vivo.. Journal of virology, 2007.
  87. Hryniewicz A, Price DA, Moniuszko M, Boasso A, Edghill-Spano Y, West SM, Venzon D, Vaccari M, Tsai WP, Tryniszewska E, Nacsa J, Villinger F, Ansari AA, Trindade CJ, Morre M, Brooks D, Arlen P, Brown HJ, Kitchen CM, Zack JA, Douek DC, Shearer GM, Lewis MG, Koup RA, Franchini G. Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques.. Journal of immunology (Baltimore, Md. : 1950), 2007.
  88. Vatakis DN, Bristol G, Wilkinson TA, Chow SA, Zack JA. Immediate activation fails to rescue efficient human immunodeficiency virus replication in quiescent CD4+ T cells.. Journal of virology, 2007.
  89. Ahuja SK, Aiuti F, Berkhout B, Biberfeld P, Burton DR, Colizzi V, Deeks SG, Desrosiers RC, Dierich MP, Doms RW, Emerman M, Gallo RC, Girard M, Greene WC, Hoxie JA, Hunter E, Klein G, Korber B, Kuritzkes DR, Lederman MM, Malim MH, Marx PA, McCune JM, McMichael A, Miller C, Miller V, Montagnier L, Montefiori DC, Moore JP, Nixon DF, Overbaugh J, Pauza CD, Richman DD, Saag MS, Sattentau Q, Schooley RT, Shattock R, Shaw GM, Stevenson M, Trkola A, Wainberg MA, Weiss RA, Wolinsky S, Zack JA. A plea for justice for jailed medical workers.. Science (New York, N.Y.), 2006.
  90. Bernstein HB, Plasterer MC, Schiff SE, Kitchen CM, Kitchen S, Zack JA. CD4 expression on activated NK cells: ligation of CD4 induces cytokine expression and cell migration.. Journal of immunology (Baltimore, Md. : 1950), 2006.
  91. Galic Z, Kitchen SG, Kacena A, Subramanian A, Burke B, Cortado R, Zack JA. T lineage differentiation from human embryonic stem cells.. Proceedings of the National Academy of Sciences of the United States of America, 2006.
  92. Brown HJ, Zack JA. Animal models of HIV-1 latency and persistence.. Current opinion in HIV and AIDS, 2006.
  93. Arlen PA, Brooks DG, Gao LY, Vatakis D, Brown HJ, Zack JA. Rapid expression of human immunodeficiency virus following activation of latently infected cells.. Journal of virology, 2006.
  94. Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H. PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry.. Proceedings of the National Academy of Sciences of the United States of America, 2005.
  95. Widney DP, Breen EC, Boscardin WJ, Kitchen SG, Alcantar JM, Smith JB, Zack JA, Detels R, Martínez-Maza O. Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection.. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2005.
  96. Chang M, Brown HJ, Collado-Hidalgo A, Arevalo JM, Galic Z, Symensma TL, Tanaka L, Deng H, Zack JA, Sun R, Cole SW. beta-Adrenoreceptors reactivate Kaposi's sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTA.. Journal of virology, 2005.
  97. Brooks DG, Cohen MD, Jamieson BD, Poon B, Kitchen SG, Chow SA, Chen IS, Zack JA, Koka PS. Rapid size dependent deletion of foreign gene sequences inserted into attenuated HIV-1 upon infection in vivo: implications for vaccine development.. Current HIV research, 2005.
  98. Kitchen SG, Whitmire JK, Jones NR, Galic Z, Kitchen CM, Ahmed R, Zack JA. The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens.. Proceedings of the National Academy of Sciences of the United States of America, 2005.
  99. Brown HJ, McBride WH, Zack JA, Sun R. Prostratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirus.. Antiviral therapy, 2005.
  100. Cole SW, Yan W, Galic Z, Arevalo J, Zack JA. Expression-based monitoring of transcription factor activity: the TELiS database.. Bioinformatics (Oxford, England), 2004.
  101. Kitchen SG, Jones NR, LaForge S, Whitmire JK, Vu BA, Galic Z, Brooks DG, Brown SJ, Kitchen CM, Zack JA. CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection.. Proceedings of the National Academy of Sciences of the United States of America, 2004.
  102. Chen H, Zha J, Gowans RE, Camargo P, Nishitani J, McQuirter JL, Cole SW, Zack JA, Liu X. Alcohol enhances HIV type 1 infection in normal human oral keratinocytes by up-regulating cell-surface CXCR4 coreceptor.. AIDS research and human retroviruses, 2004.
  103. Richlin VA, Arevalo JM, Zack JA, Cole SW. Stress-induced enhancement of NF-kappaB DNA-binding in the peripheral blood leukocyte pool: effects of lymphocyte redistribution.. Brain, behavior, and immunity, 2004.
  104. Amado RG, Mitsuyasu RT, Rosenblatt JD, Ngok FK, Bakker A, Cole S, Chorn N, Lin LS, Bristol G, Boyd MP, MacPherson JL, Fanning GC, Todd AV, Ely JA, Zack JA, Symonds GP. Anti-human immunodeficiency virus hematopoietic progenitor cell-delivered ribozyme in a phase I study: myeloid and lymphoid reconstitution in human immunodeficiency virus type-1-infected patients.. Human gene therapy, 2004.
  105. Burton DR, Desrosiers RC, Doms RW, Feinberg MB, Gallo RC, Hahn B, Hoxie JA, Hunter E, Korber B, Landay A, Lederman MM, Lieberman J, McCune JM, Moore JP, Nathanson N, Picker L, Richman D, Rinaldo C, Stevenson M, Watkins DI, Wolinsky SM, Zack JA. Public health. A sound rationale needed for phase III HIV-1 vaccine trials.. Science (New York, N.Y.), 2004.
  106. Ali A, Lubong R, Ng H, Brooks DG, Zack JA, Yang OO. Impacts of epitope expression kinetics and class I downregulation on the antiviral activity of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes.. Journal of virology, 2004.
  107. Moore JP, Kitchen SG, Pugach P, Zack JA. The CCR5 and CXCR4 coreceptors--central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection.. AIDS research and human retroviruses, 2004.
  108. Cole SW, Kemeny ME, Fahey JL, Zack JA, Naliboff BD. Psychological risk factors for HIV pathogenesis: mediation by the autonomic nervous system.. Biological psychiatry, 2003.
  109. Brooks DG, Arlen PA, Gao L, Kitchen CM, Zack JA. Identification of T cell-signaling pathways that stimulate latent HIV in primary cells.. Proceedings of the National Academy of Sciences of the United States of America, 2003.
  110. Cole SW, Galic Z, Zack JA. Controlling false-negative errors in microarray differential expression analysis: a PRIM approach.. Bioinformatics (Oxford, England), 2003.
  111. Brooks DG, Hamer DH, Arlen PA, Gao L, Bristol G, Kitchen CM, Berger EA, Zack JA. Molecular characterization, reactivation, and depletion of latent HIV.. Immunity, 2003.
  112. Liu X, Zha J, Nishitani J, Chen H, Zack JA. HIV-1 infection in peripheral blood lymphocytes (PBLs) exposed to alcohol.. Virology, 2003.
  113. Liu X, Zha J, Chen H, Nishitani J, Camargo P, Cole SW, Zack JA. Human immunodeficiency virus type 1 infection and replication in normal human oral keratinocytes.. Journal of virology, 2003.
  114. Koka PS, Brooks DG, Razai A, Kitchen CM, Zack JA. HIV type 1 infection alters cytokine mRNA expression in thymus.. AIDS research and human retroviruses, 2003.
  115. Scripture-Adams DD, Brooks DG, Korin YD, Zack JA. Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype.. Journal of virology, 2002.
  116. Korin YD, Brooks DG, Brown S, Korotzer A, Zack JA. Effects of prostratin on T-cell activation and human immunodeficiency virus latency.. Journal of virology, 2002.
  117. Cole AM, Hong T, Boo LM, Nguyen T, Zhao C, Bristol G, Zack JA, Waring AJ, Yang OO, Lehrer RI. Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1.. Proceedings of the National Academy of Sciences of the United States of America, 2002.
  118. Roth MD, Tashkin DP, Choi R, Jamieson BD, Zack JA, Baldwin GC. Cocaine enhances human immunodeficiency virus replication in a model of severe combined immunodeficient mice implanted with human peripheral blood leukocytes.. The Journal of infectious diseases, 2002.
  119. Brooks DG, Zack JA. Effect of latent human immunodeficiency virus infection on cell surface phenotype.. Journal of virology, 2002.
  120. Kitchen SG, LaForge S, Patel VP, Kitchen CM, Miceli MC, Zack JA. Activation of CD8 T cells induces expression of CD4, which functions as a chemotactic receptor.. Blood, 2002.