Publications

1. Reis FMCV, Maesta-Pereira S, Ollivier M, Schuette PJ, Sethi E, Miranda BA, Iniguez E, Chakerian M, Vaughn E, Sehgal M, Nguyen DCT, Yuan FTH, Torossian A, Ikebara JM, Kihara AH, Silva AJ, Kao JC, Khakh BS, Adhikari A. Control of feeding by a bottom-up midbrain-subthalamic pathway.. Nature communications, 2024.
2. Ollivier M, Soto JS, Linker KE, Moye SL, Jami-Alahmadi Y, Jones AE, Divakaruni AS, Kawaguchi R, Wohlschlegel JA, Khakh BS. Crym-positive striatal astrocytes gate perseverative behaviour.. Nature, 2024.
3. Zipursky S, Lee J, Sergeeva A, Ahlsen G, Mannepalli S, Bahna F, Goodman K, Khakh B, Weiner J, Shapiro L, Honig B. Astrocyte morphogenesis requires self-recognition.. Research square, 2024.
4. Iyer M, Kantarci H, Cooper MH, Ambiel N, Novak SW, Andrade LR, Lam M, Jones G, Münch AE, Yu X, Khakh BS, Manor U, Zuchero JB. Oligodendrocyte calcium signaling promotes actin-dependent myelin sheath extension.. Nature communications, 2024.
5. Soto JS, Jami-Alahmadi Y, Wohlschlegel JA, Khakh BS. In vivo identification of astrocyte and neuron subproteomes by proximity-dependent biotinylation.. Nature protocols, 2023.
6. Baldwin KT, Murai KK, Khakh BS. Astrocyte morphology.. Trends in cell biology, 2023.
7. Soto JS, Jami-Alahmadi Y, Chacon J, Moye SL, Diaz-Castro B, Wohlschlegel JA, Khakh BS. Astrocyte-neuron subproteomes and obsessive-compulsive disorder mechanisms.. Nature, 2023.
8. Iyer M, Kantarci H, Ambiel N, Novak SW, Andrade LR, Lam M, Münch AE, Yu X, Khakh BS, Manor U, Zuchero JB. Oligodendrocyte calcium signaling sculpts myelin sheath morphology.. bioRxiv : the preprint server for biology, 2023.
9. Soto JS, Khakh BS. Cell morphology: Astrocyte structure at the nanoscale.. Current biology : CB, 2023.
10. Khakh BS, Goldman SA. Astrocytic contributions to Huntington's disease pathophysiology.. Annals of the New York Academy of Sciences, 2023.
11. Gangwani MR, Soto JS, Jami-Alahmadi Y, Tiwari S, Kawaguchi R, Wohlschlegel JA, Khakh BS. Neuronal and astrocytic contributions to Huntington's disease dissected with zinc finger protein transcriptional repressors.. Cell reports, 2023.
12. Institoris A, Vandal M, Peringod G, Catalano C, Tran CH, Yu X, Visser F, Breiteneder C, Molina L, Khakh BS, Nguyen MD, Thompson RJ, Gordon GR. Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice.. Nature communications, 2022.
13. Endo F, Kasai A, Soto JS, Yu X, Qu Z, Hashimoto H, Gradinaru V, Kawaguchi R, Khakh BS. Molecular basis of astrocyte diversity and morphology across the CNS in health and disease.. Science (New York, N.Y.), 2022.
14. Badia-Soteras A, Heistek TS, Kater MSJ, Mak A, Negrean A, van den Oever MC, Mansvelder HD, Khakh BS, Min R, Smit AB, Verheijen MHG. Retraction of Astrocyte Leaflets From the Synapse Enhances Fear Memory.. Biological psychiatry, 2022.
15. Cho FS, Vainchtein ID, Voskobiynyk Y, Morningstar AR, Aparicio F, Higashikubo B, Ciesielska A, Broekaart DWM, Anink JJ, van Vliet EA, Yu X, Khakh BS, Aronica E, Molofsky AV, Paz JT. Enhancing GAT-3 in thalamic astrocytes promotes resilience to brain injury in rodents.. Science translational medicine, 2022.
16. Bravo-Ferrer I, Khakh BS, Díaz-Castro B. Cell-specific RNA purification to study translatomes of mouse central nervous system.. STAR protocols, 2022.
17. Yu X, Khakh BS. SnapShot: Astrocyte interactions.. Cell, 2022.
18. Diaz-Castro B, Bernstein AM, Coppola G, Sofroniew MV, Khakh BS. Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation.. Cell reports, 2021.
19. Nagai J, Bellafard A, Qu Z, Yu X, Ollivier M, Gangwani MR, Diaz-Castro B, Coppola G, Schumacher SM, Golshani P, Gradinaru V, Khakh BS. Specific and behaviorally consequential astrocyte Gq GPCR signaling attenuation in vivo with iβARK.. Neuron, 2021.
20. Yu X, Moye SL, Khakh BS. Local and CNS-Wide Astrocyte Intracellular Calcium Signaling Attenuation In Vivo with CalExflox Mice.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021.
21. Wang W, Schuette PJ, Nagai J, Tobias BC, Cuccovia V Reis FM, Ji S, de Lima MAX, La-Vu MQ, Maesta-Pereira S, Chakerian M, Leonard SJ, Lin L, Severino AL, Cahill CM, Canteras NS, Khakh BS, Kao JC, Adhikari A. Coordination of escape and spatial navigation circuits orchestrates versatile flight from threats.. Neuron, 2021.
22. Kronschläger MT, Siegert ASM, Resch FJ, Rajendran PS, Khakh BS, Sandkühler J. Lamina-specific properties of spinal astrocytes.. Glia, 2021.
23. Rajbhandari AK, Octeau CJ, Gonzalez S, Pennington ZT, Mohamed F, Trott J, Chavez J, Ngyuen E, Keces N, Hong WZ, Neve RL, Waschek J, Khakh BS, Fanselow MS. A Basomedial Amygdala to Intercalated Cells Microcircuit Expressing PACAP and Its Receptor PAC1 Regulates Contextual Fear.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021.
24. Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A. Reactive astrocyte nomenclature, definitions, and future directions.. Nature neuroscience, 2021.
25. Nagai J, Yu X, Papouin T, Cheong E, Freeman MR, Monk KR, Hastings MH, Haydon PG, Rowitch D, Shaham S, Khakh BS. Behaviorally consequential astrocytic regulation of neural circuits.. Neuron, 2020.
26. Yu X, Nagai J, Marti-Solano M, Soto JS, Coppola G, Babu MM, Khakh BS. Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable.. Neuron, 2020.
27. Bassett DS, Cullen KE, Eickhoff SB, Farah MJ, Goda Y, Haggard P, Hu H, Hurd YL, Josselyn SA, Khakh BS, Knoblich JA, Poirazi P, Poldrack RA, Prinz M, Roelfsema PR, Spires-Jones TL, Sur M, Ueda HR. Reflections on the past two decades of neuroscience.. Nature reviews. Neuroscience, 2020.
28. Murphy-Royal C, Johnston AD, Boyce AKJ, Diaz-Castro B, Institoris A, Peringod G, Zhang O, Stout RF, Spray DC, Thompson RJ, Khakh BS, Bains JS, Gordon GR. Author Correction: Stress gates an astrocytic energy reservoir to impair synaptic plasticity.. Nature communications, 2020.
29. Murphy-Royal C, Johnston AD, Boyce AKJ, Diaz-Castro B, Institoris A, Peringod G, Zhang O, Stout RF, Spray DC, Thompson RJ, Khakh BS, Bains JS, Gordon GR. Stress gates an astrocytic energy reservoir to impair synaptic plasticity.. Nature communications, 2020.
30. Badia-Soteras A, Octeau JC, Verheijen MHG, Khakh BS. Assessing Neuron-Astrocyte Spatial Interactions Using the Neuron-Astrocyte Proximity Assay.. Current protocols in neuroscience, 2020.
31. Yu X, Nagai J, Khakh BS. Improved tools to study astrocytes.. Nature reviews. Neuroscience, 2020.
32. Shuman T, Aharoni D, Cai DJ, Lee CR, Chavlis S, Page-Harley L, Vetere LM, Feng Y, Yang CY, Mollinedo-Gajate I, Chen L, Pennington ZT, Taxidis J, Flores SE, Cheng K, Javaherian M, Kaba CC, Rao N, La-Vu M, Pandi I, Shtrahman M, Bakhurin KI, Masmanidis SC, Khakh BS, Poirazi P, Silva AJ, Golshani P. Breakdown of spatial coding and interneuron synchronization in epileptic mice.. Nature neuroscience, 2020.
33. Diaz-Castro B, Gangwani MR, Yu X, Coppola G, Khakh BS. Astrocyte molecular signatures in Huntington's disease.. Science translational medicine, 2019.
34. Moye SL, Diaz-Castro B, Gangwani MR, Khakh BS. Visualizing Astrocyte Morphology Using Lucifer Yellow Iontophoresis.. Journal of visualized experiments : JoVE, 2019.
35. Khakh BS. Astrocyte-Neuron Interactions in the Striatum: Insights on Identity, Form, and Function.. Trends in neurosciences, 2019.
36. Khakh BS, Deneen B. The Emerging Nature of Astrocyte Diversity.. Annual review of neuroscience, 2019.
37. Octeau JC, Gangwani MR, Allam SL, Tran D, Huang S, Hoang-Trong TM, Golshani P, Rumbell TH, Kozloski JR, Khakh BS. Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation.. Cell reports, 2019.
38. Nagai J, Rajbhandari AK, Gangwani MR, Hachisuka A, Coppola G, Masmanidis SC, Fanselow MS, Khakh BS. Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue.. Cell, 2019.
39. Lobas MA, Tao R, Nagai J, Kronschläger MT, Borden PM, Marvin JS, Looger LL, Khakh BS. A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP.. Nature communications, 2019.
40. Giovannucci A, Friedrich J, Gunn P, Kalfon J, Brown BL, Koay SA, Taxidis J, Najafi F, Gauthier JL, Zhou P, Khakh BS, Tank DW, Chklovskii DB, Pnevmatikakis EA. CaImAn an open source tool for scalable calcium imaging data analysis.. eLife, 2019.
41. Aharoni D, Khakh BS, Silva AJ, Golshani P. All the light that we can see: a new era in miniaturized microscopy.. Nature methods, 2019.
42. Yu X, Taylor AMW, Nagai J, Golshani P, Evans CJ, Coppola G, Khakh BS. Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior.. Neuron, 2018.
43. Khennouf L, Gesslein B, Brazhe A, Octeau JC, Kutuzov N, Khakh BS, Lauritzen M. Active role of capillary pericytes during stimulation-induced activity and spreading depolarization.. Brain : a journal of neurology, 2018.
44. Octeau JC, Faas G, Mody I, Khakh BS. Making, Testing, and Using Potassium Ion Selective Microelectrodes in Tissue Slices of Adult Brain.. Journal of visualized experiments : JoVE, 2018.
45. Octeau JC, Chai H, Jiang R, Bonanno SL, Martin KC, Khakh BS. An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales.. Neuron, 2018.
46. Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG. Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection.. Cell reports, 2017.
47. Chai H, Diaz-Castro B, Shigetomi E, Monte E, Octeau JC, Yu X, Cohn W, Rajendran PS, Vondriska TM, Whitelegge JP, Coppola G, Khakh BS. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.. Neuron, 2017.
48. Khakh BS, Beaumont V, Cachope R, Munoz-Sanjuan I, Goldman SA, Grantyn R. Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease.. Trends in neurosciences, 2017.
49. Srinivasan R, Lu TY, Chai H, Xu J, Huang BS, Golshani P, Coppola G, Khakh BS. New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo.. Neuron, 2016.
50. Xu J, Bernstein AM, Wong A, Lu XH, Khoja S, Yang XW, Davies DL, Micevych P, Sofroniew MV, Khakh BS. P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016.
51. Anderson MA, Burda JE, Ren Y, Ao Y, O'Shea TM, Kawaguchi R, Coppola G, Khakh BS, Deming TJ, Sofroniew MV. Astrocyte scar formation aids central nervous system axon regeneration.. Nature, 2016.
52. Jiang R, Diaz-Castro B, Looger LL, Khakh BS. Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016.
53. Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV. Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium.. Frontiers in neuroscience, 2016.
54. Shigetomi E, Patel S, Khakh BS. Probing the Complexities of Astrocyte Calcium Signaling.. Trends in cell biology, 2016.
55. Olsen ML, Khakh BS, Skatchkov SN, Zhou M, Lee CJ, Rouach N. New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015.
56. Khakh BS, Sofroniew MV. Diversity of astrocyte functions and phenotypes in neural circuits.. Nature neuroscience, 2015.
57. Srinivasan R, Huang BS, Venugopal S, Johnston AD, Chai H, Zeng H, Golshani P, Khakh BS. Ca(2+) signaling in astrocytes from Ip3r2(-/-) mice in brain slices and during startle responses in vivo.. Nature neuroscience, 2015.
58. Khakh BS, McCarthy KD. Astrocyte calcium signaling: from observations to functions and the challenges therein.. Cold Spring Harbor perspectives in biology, 2015.
59. Jiang R, Haustein MD, Sofroniew MV, Khakh BS. Imaging intracellular Ca²⁺ signals in striatal astrocytes from adult mice using genetically-encoded calcium indicators.. Journal of visualized experiments : JoVE, 2014.
60. Burnstock G, Nistri A, Khakh BS, Giniatullin R. ATP-gated P2X receptors in health and disease.. Frontiers in cellular neuroscience, 2014.
61. Xu J, Khakh BS. Slow neuromodulation mediated by ATP P2X receptors.. Neuron, 2014.
62. Xu J, Chai H, Ehinger K, Egan TM, Srinivasan R, Frick M, Khakh BS. Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorin.. The Journal of general physiology, 2014.
63. Khakh BS, Sofroniew MV. Astrocytes and Huntington's disease.. ACS chemical neuroscience, 2014.
64. Haustein MD, Kracun S, Lu XH, Shih T, Jackson-Weaver O, Tong X, Xu J, Yang XW, O'Dell TJ, Marvin JS, Ellisman MH, Bushong EA, Looger LL, Khakh BS. Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway.. Neuron, 2014.
65. Gray EE, Guglietta R, Khakh BS, O'Dell TJ. Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.. The Journal of biological chemistry, 2014.
66. Tong X, Ao Y, Faas GC, Nwaobi SE, Xu J, Haustein MD, Anderson MA, Mody I, Olsen ML, Sofroniew MV, Khakh BS. Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice.. Nature neuroscience, 2014.
67. Zhang S, Anderson MA, Ao Y, Khakh BS, Fan J, Deming TJ, Sofroniew MV. Tunable diblock copolypeptide hydrogel depots for local delivery of hydrophobic molecules in healthy and injured central nervous system.. Biomaterials, 2013.
68. Shigetomi E, Jackson-Weaver O, Huckstepp RT, O'Dell TJ, Khakh BS. TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013.
69. Housley GD, Morton-Jones R, Vlajkovic SM, Telang RS, Paramananthasivam V, Tadros SF, Wong AC, Froud KE, Cederholm JM, Sivakumaran Y, Snguanwongchai P, Khakh BS, Cockayne DA, Thorne PR, Ryan AF. ATP-gated ion channels mediate adaptation to elevated sound levels.. Proceedings of the National Academy of Sciences of the United States of America, 2013.
70. Shigetomi E, Bushong EA, Haustein MD, Tong X, Jackson-Weaver O, Kracun S, Xu J, Sofroniew MV, Ellisman MH, Khakh BS. Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses.. The Journal of general physiology, 2013.
71. Tong X, Shigetomi E, Looger LL, Khakh BS. Genetically encoded calcium indicators and astrocyte calcium microdomains.. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2012.
72. Hamby ME, Coppola G, Ao Y, Geschwind DH, Khakh BS, Sofroniew MV. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012.
73. Khakh BS, North RA. Neuromodulation by extracellular ATP and P2X receptors in the CNS.. Neuron, 2012.
74. Akerboom J, Chen TW, Wardill TJ, Tian L, Marvin JS, Mutlu S, Calderón NC, Esposti F, Borghuis BG, Sun XR, Gordus A, Orger MB, Portugues R, Engert F, Macklin JJ, Filosa A, Aggarwal A, Kerr RA, Takagi R, Kracun S, Shigetomi E, Khakh BS, Baier H, Lagnado L, Wang SS, Bargmann CI, Kimmel BE, Jayaraman V, Svoboda K, Kim DS, Schreiter ER, Looger LL. Optimization of a GCaMP calcium indicator for neural activity imaging.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012.
75. Toulme E, Khakh BS. Imaging P2X4 receptor lateral mobility in microglia: regulation by calcium and p38 MAPK.. The Journal of biological chemistry, 2012.
76. Samways DS, Khakh BS, Egan TM. Allosteric modulation of Ca2+ flux in ligand-gated cation channel (P2X4) by actions on lateral portals.. The Journal of biological chemistry, 2012.
77. Shigetomi E, Tong X, Kwan KY, Corey DP, Khakh BS. TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3.. Nature neuroscience, 2011.
78. Richler E, Shigetomi E, Khakh BS. Neuronal P2X2 receptors are mobile ATP sensors that explore the plasma membrane when activated.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011.
79. Samways DS, Khakh BS, Dutertre S, Egan TM. Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors).. Proceedings of the National Academy of Sciences of the United States of America, 2011.
80. Reeves AM, Shigetomi E, Khakh BS. Bulk loading of calcium indicator dyes to study astrocyte physiology: key limitations and improvements using morphological maps.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011.
81. Shigetomi E, Kracun S, Khakh BS. Monitoring astrocyte calcium microdomains with improved membrane targeted GCaMP reporters.. Neuron glia biology, 2010.
82. Shigetomi E, Kracun S, Sofroniew MV, Khakh BS. A genetically targeted optical sensor to monitor calcium signals in astrocyte processes.. Nature neuroscience, 2010.
83. Toulme E, Garcia A, Samways D, Egan TM, Carson MJ, Khakh BS. P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin.. The Journal of general physiology, 2010.
84. Kracun S, Chaptal V, Abramson J, Khakh BS. Gated access to the pore of a P2X receptor: structural implications for closed-open transitions.. The Journal of biological chemistry, 2010.
85. Khakh BS, Burnstock G. The double life of ATP.. Scientific American, 2009.
86. Singh H, Warburton S, Vondriska TM, Khakh BS. Proteomics to identify proteins interacting with P2X2 ligand-gated cation channels.. Journal of visualized experiments : JoVE, 2009.
87. Shigetomi E, Khakh BS. Measuring near plasma membrane and global intracellular calcium dynamics in astrocytes.. Journal of visualized experiments : JoVE, 2009.
88. Chaumont S, Compan V, Toulme E, Richler E, Housley GD, Rassendren F, Khakh BS. Regulation of P2X2 receptors by the neuronal calcium sensor VILIP1.. Science signaling, 2008.
89. Samways DS, Khakh BS, Egan TM. Tunable calcium current through TRPV1 receptor channels.. The Journal of biological chemistry, 2008.
90. Chaumont S, Khakh BS. Patch-clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels.. Proceedings of the National Academy of Sciences of the United States of America, 2008.
91. Young MT, Fisher JA, Fountain SJ, Ford RC, North RA, Khakh BS. Molecular shape, architecture, and size of P2X4 receptors determined using fluorescence resonance energy transfer and electron microscopy.. The Journal of biological chemistry, 2008.
92. Jarvis MF, Khakh BS. ATP-gated P2X cation-channels.. Neuropharmacology, 2008.
93. Shigetomi E, Bowser DN, Sofroniew MV, Khakh BS. Two forms of astrocyte calcium excitability have distinct effects on NMDA receptor-mediated slow inward currents in pyramidal neurons.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008.
94. Khakh BS. ATP-gated P2X receptors on excitatory nerve terminals onto interneurons initiate a form of asynchronous glutamate release.. Neuropharmacology, 2008.
95. Richler E, Chaumont S, Shigetomi E, Sagasti A, Khakh BS. Tracking transmitter-gated P2X cation channel activation in vitro and in vivo.. Nature methods, 2007.
96. Bowser DN, Khakh BS. Vesicular ATP is the predominant cause of intercellular calcium waves in astrocytes.. The Journal of general physiology, 2007.
97. Bowser DN, Khakh BS. Two forms of single-vesicle astrocyte exocytosis imaged with total internal reflection fluorescence microscopy.. Proceedings of the National Academy of Sciences of the United States of America, 2007.
98. Khakh BS, North RA. P2X receptors as cell-surface ATP sensors in health and disease.. Nature, 2006.
99. Khakh BS, Fisher JA, Nashmi R, Bowser DN, Lester HA. An angstrom scale interaction between plasma membrane ATP-gated P2X2 and alpha4beta2 nicotinic channels measured with fluorescence resonance energy transfer and total internal reflection fluorescence microscopy.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005.
100. Khakh BS, Egan TM. Contribution of transmembrane regions to ATP-gated P2X2 channel permeability dynamics.. The Journal of biological chemistry, 2004.
101. Fisher JA, Girdler G, Khakh BS. Time-resolved measurement of state-specific P2X2 ion channel cytosolic gating motions.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004.
102. Bowser DN, Khakh BS. ATP excites interneurons and astrocytes to increase synaptic inhibition in neuronal networks.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004.
103. Egan TM, Khakh BS. Contribution of calcium ions to P2X channel responses.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004.
104. Girdler G, Khakh BS. ATP-gated P2X channels.. Current biology : CB, 2004.
105. Khakh BS, Gittermann D, Cockayne DA, Jones A. ATP modulation of excitatory synapses onto interneurons.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003.
106. Eickhorst AN, Berson A, Cockayne D, Lester HA, Khakh BS. Control of P2X(2) channel permeability by the cytosolic domain.. The Journal of general physiology, 2002.
107. Khakh BS, Smith WB, Chiu CS, Ju D, Davidson N, Lester HA. Activation-dependent changes in receptor distribution and dendritic morphology in hippocampal neurons expressing P2X2-green fluorescent protein receptors.. Proceedings of the National Academy of Sciences of the United States of America, 2001.
108. Khakh BS, Burnstock G, Kennedy C, King BF, North RA, Séguéla P, Voigt M, Humphrey PP. International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.. Pharmacological reviews, 2001.
109. Khakh BS. Molecular physiology of P2X receptors and ATP signalling at synapses.. Nature reviews. Neuroscience, 2001.
110. Labarca C, Schwarz J, Deshpande P, Schwarz S, Nowak MW, Fonck C, Nashmi R, Kofuji P, Dang H, Shi W, Fidan M, Khakh BS, Chen Z, Bowers BJ, Boulter J, Wehner JM, Lester HA. Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety.. Proceedings of the National Academy of Sciences of the United States of America, 2001.
111. Patel MK, Khakh BS, Henderson G. Properties of native P2X receptors in rat trigeminal mesencephalic nucleus neurones: lack of correlation with known, heterologously expressed P2X receptors.. Neuropharmacology, 2001.
112. Khakh BS, Zhou X, Sydes J, Galligan JJ, Lester HA. State-dependent cross-inhibition between transmitter-gated cation channels.. Nature, 2000.
113. Khakh BS, Henderson G. Modulation of fast synaptic transmission by presynaptic ligand-gated cation channels.. Journal of the autonomic nervous system, 2000.
114. Khakh BS, Proctor WR, Dunwiddie TV, Labarca C, Lester HA. Allosteric control of gating and kinetics at P2X(4) receptor channels.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999.
115. Khakh BS, Lester HA. Dynamic selectivity filters in ion channels.. Neuron, 1999.
116. Khakh BS, Bao XR, Labarca C, Lester HA. Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds.. Nature neuroscience, 1999.
117. Khakh BS, Henderson G. ATP receptor-mediated enhancement of fast excitatory neurotransmitter release in the brain.. Molecular pharmacology, 1998.
118. Khakh BS, Henderson G. Hyperpolarization-activated cationic currents (Ih) in neurones of the trigeminal mesencephalic nucleus of the rat.. The Journal of physiology, 1998.
119. Khakh BS, Kennedy C. Adenosine and ATP: progress in their receptors' structures and functions.. Trends in pharmacological sciences, 1998.
120. Khakh BS, Humphrey PP, Henderson G. ATP-gated cation channels (P2X purinoceptors) in trigeminal mesencephalic nucleus neurons of the rat.. The Journal of physiology, 1997.
121. Humphrey PP, Buell G, Kennedy I, Khakh BS, Michel AD, Surprenant A, Trezise DJ. New insights on P2X purinoceptors.. Naunyn-Schmiedeberg's archives of pharmacology, 1995.
122. Trezise DJ, Michel AD, Grahames CB, Khakh BS, Surprenant A, Humphrey PP. The selective P2X purinoceptor agonist, beta,gamma-methylene-L-adenosine 5'-triphosphate, discriminates between smooth muscle and neuronal P2X purinoceptors.. Naunyn-Schmiedeberg's archives of pharmacology, 1995.
123. Khakh BS, Surprenant A, Humphrey PP. A study on P2X purinoceptors mediating the electrophysiological and contractile effects of purine nucleotides in rat vas deferens.. British journal of pharmacology, 1995.
124. Khakh BS, Humphrey PP, Surprenant A. Electrophysiological properties of P2X-purinoceptors in rat superior cervical, nodose and guinea-pig coeliac neurones.. The Journal of physiology, 1995.
125. Khakh BS, Michel A, Humphrey PP. Estimates of antagonist affinities at P2X purinoceptors in rat vas deferens.. European journal of pharmacology, 1994.
126. Trezise DJ, Bell NJ, Khakh BS, Michel AD, Humphrey PA. P2 purinoceptor antagonist properties of pyridoxal-5-phosphate.. European journal of pharmacology, 1994.